1948 Volume 68 Issue 7-9 Pages 216-217
Sulfide compounds obtained by reacting bromo-acetal to the sodium salts of p-thiocresol or p-nitrothiophenol is oxidized to sulfonacetal, brominated in glacial AcOH and condensed with thiourea to 2-amino-5-p-tolysulfone- and 2-amino-5-p-nitro-benzenesulfone-thiazole, respectively, Latter is reduced to Promizole (2-amino-5-p-aminobenzenesulfone-thiazole).