Study of Antimalarials having Alicyclic Base as a Side-Chain. I

2-Chloro-5-(4′-diethylaminocyclohexyl)-amino-7-methoxyacridine

Abstract

2-Chloro-5-(4′-diethylaminocyclohexyl)-amino-7-methoxyacridine, a new compound having N, N-diethylcyclohexylene-diamine (1, 4) radical instead of the basic side-chain of atabrin, δ-diethylamino-α-methylbutylamine, was synthesized by the condensation of N, N-diethylcyclohexylene-diamine (1, 4) and 2-chloro-5-phenoxy-7-methoxyacridine. This antimalarial having the side-chain which is more easily synthesized than that of atabrin, showed about the same (cis-form) or better (trans-form) therapeutic effect as atabrin by animal tests usiug innoculated canaries.