Arylsulfone-thiazole誘導體の合成研究 (第4報)

2-amino-5-p-aminobenzenesulfone-thiazole (Promizole) の合成に就いて

抄録

Sulfide compounds obtained by reacting bromo-acetal to the sodium salts of p-thiocresol or p-nitrothiophenol is oxidized to sulfonacetal, brominated in glacial AcOH and condensed with thiourea to 2-amino-5-p-tolysulfone- and 2-amino-5-p-nitro-benzenesulfone-thiazole, respectively, Latter is reduced to Promizole (2-amino-5-p-aminobenzenesulfone-thiazole).