Studies on the Reductive Acylamination. III

Reductive Acylamination of Oximes

Abstract

In the manner similar to the case of the nitriles as reported in II, oximes were hydrogenated over nickel catalysts at high temperature and high pressure in the presence of formamide or ethyl formate. Experiments were carried out used as oximes benzaldoxime, p-sulfonamidobenzaldoxime, acetaldoxime, n-butyraldoxime, acetoxime and acetophenoxime. Corresponding formylamino derivatives were regularly obtained but the yield was not as good as in the case of nitriles, except in the case of aromatic aldehydes.