Studies on the Reductive Acylamination. IV

Reductive Acylamination of Carbonyl Compounds in the Presence of Ammonia

Abstract

Hydrogenation of carbonyl compounds over Raney nickel at high temperature and high pressure in the presence of ammonia and formamide gave formylamino derivatives. The carbonyl compounds used were benzaldehyde, p-sulfonamidobenzaldehyde, n-butyraldehyde, acetophenone and phenylacetone. The yield of formamides was good in aromatic carbonyl compounds, side reaction being suppressed. Yield of formylamino derivatives were comparatively poor from aliphatic carbonyl compounds.