脂肪属アミンの分離定量法について

抄録

Isolation of aliphatic primary, secondary and tertiary amines, including ammonia, by partial neutralization and steam distillation was carried out, with examination of the purity of each amine distillate. These amines can be classified into strongly basic group (primary and secondary amines) and the weakly basic group (tertiary amine and ammonia). Partial neutralization allows separation of amines from a mixture of the two groups, but does not make it possible to separate the amines of one group into each component. Quantitative estimation of amines were carried out by the van Slyke method for primary amines with ammonia, the tertiary amines after treatment with nitrous acid, secondary amines, by the difference with total basicity, and ammonia, by Na₃Co(NO₂)₆ as described in the previous report. From this result, a systematic method of isolation of aliphatic amine hydrochloride was completed.
Extraction of the hydrochloride of amines by chloroform results in solution of the secondary and tertiary amine hydrochlorides with primary amine hydrochloride and ammonium chloride remaining in the solution. Since each of these groups are combinations of strongly and weakly basic compounds, the respective components can be isolated by partial neutralization.