Abstract
1) Aromatic amines were thiocyanated and led to sulfanilamides by which following new sulfanilamides were synthesized: p-Sulfanilamide-, p-sulfanilamide-o-methyl-, p-sulfanilamide-m-methyl-, p-sulfanilamide-o-carbomethoxy- and p-sulfanilamide-o-carbethoxy-thiocyanobenzenes, and 2-sulfanilamide-6-methylbenzothiazole.
2) p-Sulfanilamide-, p-sulfanilamide-o-methyl- and p-sulfanilamide-m-methyl-thiocyanobenzenes are not antagonistic to p-aminobenzoic acid and are more powerful against cocci than sulfanilamides. In vitro tests against Staphylococcus aureus showed them to be over ten times more powerful than sulfathiazole. These compounds were found to be effective against C. diphtheriae, Streptococcus haemolyticus, Staphylococcus aureus, Br. melitenses, Br. abortus suis and B. anthracis. Inhibitory action of 2-sulfanilamide-6-methylbenzothiazole against coccus was found to be far inferior.
