Studies on the p-Nitro and p-Amino Derivatives of Diphenyl Ether

Abstract

Electrolytic pressure of 4-nitro-4, 4′-dinitro- and 4-amino-4′-nitro-diphenyl ethers were determined by the polarographic method, using mercury drop electrode. The standard pressure was found to be -0.80₇ volt for 4-nitro compound (pH 7.0); -0.59₂ and -0.65₆ volt for 4, 4′-dinitro compound (pH 7.0); and -0.84₉ volt for 4-amino-4′-nitro compound (pH 7.0).
Partial reduction of 4, 4′-dinitro compound was successfully carried out by the use of (NH₄)₂S, which gave 4-amino-4′-nitro compound.
Sedative and analgesic action of 4-amino-4′-nitro- and 4-amino-biphenyl ethers was tested by its subcutaneous injection in mice.