Synthesis of Derivatives of Dithiazolyl Sulfone. II

Synthesis of 2, 2′-Diamino-4, 4′-dimethyl-5, 5′-dithiazolyl Sulfone

Abstract

Bromination of acetonyl sulfide in benzene yields a dibromide which, by condensation with thiourea, gave bis-2-amino-4-methyl-5-thiazolyl sulfide. This sulfide can also be obtained by the reaction of 2-amino-4-methyl-5-bromothiazole and Na₂S. Acetylation of the sulfide and subsequent oxidation by 30% H₂O₂ in glacial acetic acid gave bis-2-acetamino-4-methyl-5-thiazolyl sulfone, which was hydrolyzed by conc. HCl to the objective bis-2-amino-4-methyl-5-thiazolyl sulfone.