抄録
By the application of cuprous cyanide to 4-methyl-2, 5-dibromothiazole (I) in nitrobenzene at 200-210°, 2-cyano-4-methyl-5-bromothiazole (II) and its acid amide (III) were obtained but with a very poor yield. (II) can also be obtained by the diazotization of 2-amino-4-methyl-5-bromothiazole followed by the application of cuprous cyanide to change to the nitrile. Hydrolysis of (II) yielded (III), 4-methyl-5-bromothiazole-2-carboxylic acid (VI) and its ammonium salt (V). (V) and (VI) easily liberate carbon dioxide by thermal decomposition to give 4-methyl-5-bromothiazole (VII).
