抗ヒスタミン剤の研究 (第4報)

2-Benzylaminopyrimidine類の合成 その4

抄録

2-Phenoxypyrimidine was prepared from 2-chloropyrimidine and phenol. Application of benzylamine to the former yielded 2-benzylamino pyrimidine. In a similar manner, 2-phenoxy- and 2-β-naphthoxy-4-methylpyrimidines were prepared from 2-chloro-4-methylpyrimidine and reacted with amino compounds to obtain 2-benzylamino-, 2-p-methoxybenzylamino-, 2-anilino- and 2-(dimethylaminoethyl)-amino-4-methylpyrimidines. Application of benzylamine to 2-ethoxy-4-methylpyrimidine, obtained from 2-chloro-4-methylpyrimidine, by heating resulted in the formation of a small amount of 2-benzyl-amino-4-methylpyrimidine and N, N′-dibenzylurea.