2-(パラ-アミノベンゼンスルホンアミド)-4, 5-ヂメチルピリミヂンの合成

抄録

2-(p-Aminobenzenesulfonamido)-4, 5-dimethylpyrimidine (VIII) was prepared by the condensation of methyl α-formylethyl ketone (II) or its sodium salt (I) with sulfaguanidine by means of alkaline condensing agent. N⁴-Acetylsulfaguanidine undergoes similar condensation only in acetic acid solution giving 2-(p-acetaminobenzenesulfonamido)-4, 5-dimethylpyrimidine (VII). Better results were obtained when acetals of methyl α-formylethyl ketone such as (III), (IV) or (V) was used in place of (I) and (II). 2-(p-Dimethylaminobenzenesulfonamido)-4, 5-dimethylpyrimidine was also synthesized.