Abstract
β, β-Dichloropropionaldehyde acetal, prepared from 1-bromo-3, 3-dichloropropyl acetate and appropriate alcohol, was condensed with acetylsulfaguanidine in acetic acid solution in the presence of sodium acetate, giving acetylsulfadiazine in 28% yield. When the condensation was carried out in conc. sulfuric acid, 2-aminopyrimidine was the only product isolated which owes its formation to guanidine sulfate, the degradation product of acetylsulfaguanidine by sulfuric acid.
