YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Synthesis of 2-Aminopyrimidine
Shun-ichi YamadaTadashi FujitaJun-ichiro Arita
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1951 Volume 71 Issue 12 Pages 1363-1364

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Abstract
Guanidine salts were condensed with 1-bromo-3, 3-dichloropropyl acetate (I) or β, β-dichloropropione acetal (II) in conc. sulfuric acid or in alcohol containing hydrochloric acid by which 2-aminopyrimidine was obtained in a good yield. A small amount of 2-amino-5-bromopyrimidine was formed at the same time when (I) was used as the starting material.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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