ベンチヂン系化学療法剤の研究 (第1報)
1951 年 71 巻 12 号 p. 1478-1481
詳細
1951 年 71 巻 12 号 p. 1478-1481
Some of the compounds of azo dyes of benzidine series are known to possess antiviral and antitripanosomal actions and the benzidine residue is believed to be responsible for the appearance of these activities. Based upon this assumption, about 20 kinds of compounds of sulfanilamide, p-aminobenzamide and p-hydroxybenzenesulfonamide types containing the benzidine residue were prepared and their antibacterial actions against Escherichia coli were examined. Those that showed any antibacterial action were 4, 4′-bis(p-acetamino- and p-amino-benzenesulfonamido)-diphenyl, the former approximately equal to that of sulfanilamide and the latter about that of sulfadiazine. 2-Nitro-4-(p-acetamino- and p-amino-benzenesulfonamido)-4′-acetaminodiphenyl showed similar antibacterial action as that of sulfanilamide.
