YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Synthesis of Antihistaminic Agents. III
Synthesis of Some Basic Benzhydryl Alkyl Ethers
Kunio FujiwaraMichito OhtsukaHiroichi Fukuda
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1951 Volume 71 Issue 5 Pages 367-369

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Abstract
By applying the synthetic method described in the foregoing paper, the following basic benzhydryl ethers were prepared: γ-Dimethylaminopropyl benzhydryl ether, colorless liquid, b.p4 174-176°; methiodide, colorless plates, m.p. 180-181°; picrate, yellow prisms, m.p. 117-119°. β-Dimethylaminoethyl p-dimethylaminobenzhydryl ether, pale yellow liquid, b.p1 175-182°; methiodode, colorless prisms, m.p. 175-177°; picrate, yellow plates, m.p. 117-119.5°; hydrochloride with 1/2 H2O, small scales, m.p. 138.5-139.5°. β-Dimethylaminoethyl bis-(p-dimethylamino)-benzhydryl ether, white needles, m.p. 97-97.5°.
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