Isoquinoline Ring Closure by Bischler-Napieralski-Perkin in the Presence of Tin, Zinc or Stannous Chloride. III

The Isoquinoline Cyclization of Acyl-β-methoxy-β-phenethylamide Type Compounds in the Presence of Tin or Zinc

Abstract

The use of corresponding β-methoxy derivatives (I) in place of the acid amides (I) as material for cyclization by the Bischler-Napieralski-Perkin method, also showed that the presence of a suitable amount of tin results in a larger yield and high purity of the product isoquinolines (III), similar to the case described in the previous report. The same results as described previously were found to be true as to the presence or absence of metals and the use of various solvents in the yield and purity of the products (III).