YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
The Androgen Assay Based on the Weight of Accessory Organs
Studies on Sexual Hormones. I. Studies on Sexual Hormone Assays. (1)
Yosoji ItoBun-ichi TamaokiMasako Egusa
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1952 Volume 72 Issue 1 Pages 54-60

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Abstract
Critical observations were made, using modern statistical methods, on a quantitative assay of androgen based on the response of seminal vesicle and prostate. As a result, following conclusions were made:
1) The correlation coefficient between log dose and the cube root of SVP (seminal vesicle and prostate anterior and intramedial lobe weights) was certified as being significant, and this dose-response curve was regarded statistically as the linear regression equation.
2) only when the linearity of this dose-response curve was certified by the present experiment it becomes possible to apply the statistical methods on quantitative assay for this androgen determination.
3) The correlation coefficients were significant between the cube root of the mean value of SVP and PP (prostate posterior lobe) and between their weight in individuals.
4) An interesting result obtained was that testosteron injection clearly decreased the weight of adrenal glands of castrated rats as compared to those of the control animals.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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