YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Synthesis of Local Anesthetics Not Antagonistic to Sulfonamides
Tozaburo KuriharaJiro Kitamura
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1952 Volume 72 Issue 1 Pages 76-78

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Abstract
Eleven new sulfur- or halogen-containing local anesthetics were prepared. They were alkamine esters or amidines of amino-, hydroxy-, or bromo-mercaptobenzoic acids. Eight. of these were found to be as effective as or slightly better than cocaine on rabbit cornea. Antibacterial action of the sulfa drugs against Staphylococcus or Escherichia coli is not antagonized by these anesthetics.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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