Abstract
Derivatives of p-aminophenylalkyl sulfone, p-aminomethyl-phenylalkyl sulfone and p-aminophenylalkyl ether were prepared and their antibacterial activities in vitro against Mycobacterium tuberculosis (human strain), Staphylococcus aureus and Escherichia coli were studied (Table I). The toxicities on mice and competitive action on p-aminobenzoic acid of some of the chief derivatives were also examined (Tables II and III). Results obtained were as follows: 1) Among the alkyl sulf one and ether derivatives so far obtained, n-amyl and n-hexyl compounds showed the strongest activities against tubercle bacilli in Sauton's medium. It is interesting to note that all alkyl ethers gave the same results in Kirchner's medium.
2) In antibacterial activity, the alkyl ethers were superior to alkyl sulfones but the former showed a far stronger toxicity than the latter.
3) Alkyl sulf ones were found to be more or less antagonized in their activities against M. tuberculosis and Staph. aureus by the addition of p-aminobenzoic acid. Such competitive action was not observed in the case of alkyl ethers.
