Benzothiazoles. VII
Chlorination of 2-Alkyl-6-Nitro- and 2-Alkylbenzothiazoles
1952 年 72 巻 10 号 p. 1263-1265
詳細
1952 年 72 巻 10 号 p. 1263-1265
1) Possible routes of preparing benzothiazole analogs of chloramphenicol were examined, one of which was proved to be promising. The route is as follows: 2-Ethyl-, 2-ethyl-6-nitro-, 2-dichloroethyl-6-nitro-, 2-acetyl-6-nitro-(X), and to 2-α-bromoacetyl-6-nitrobenzothiazole. Overall yield of (X) by the present route was found to be 18%.
2) During the present investigation, following new compounds were prepared: Benzothiazolyl-2-carbohydrazide, m.p. 171°; 2-acetylbenzothiazole, m.p. 107-108°, its semicarbazone, m.p. 258° (decomp.); 2-acetyl-6-nitrobenzothiazole, m.p. 191-192°; 2-α, α′-dichloro-6-nitrobenzothiazole, m.p. 93-94°; 2-bromoacetyl-6-nitrobenzothiazole, m.p. 146-147°.
