Abstract
Aminopterin and other simpler derivatives of 2, 4-diamino-4-hydroxy- or 2-amino-4-hydroxy-pteridine were synthesized and their effect upon Yoshida ascite sarcoma was also studied. It was shown that aminopterin itself causes a severe damage upon the nuclei of the tumor cells by an intraperitoneal administration of 1mg/kg, but the other simpler pteridines showed no remarkable effect upon animals within, the dosage of 10-100mg/kg.
