1952 年 72 巻 2 号 p. 172-182
It was pointed out that the method which had been used in the past reports to find the synergism between androgen and other compounds was statistically imperfect. The meaning of synergism between two compounds was newly and statistically defined as the interaction term in the design of experiments (this manner of interpretation of interaction is fairly common in the field work of agriculture).
According to this definition and the statistical procedure, it could be concluded that the acid fraction in whale testis fat hydrolysate possessed this synergistic activity but the neutral fraction had neither such activity nor androgenic activity significantly enough through SVP and PP weight tests.
Moreover, it was found that there was a significant correlation between the weight of SVP and PP which confirmed the result of our previous work, and there was no significant difference between the correlation coefficients in this experiment and in the previous experiments, after comparing them by the statistical method.
On the other hand, after analyzing the data of the body weight increase during the injections, there was no significant difference in those effects which were caused by testosterone, the acid fraction and the neutral fraction. It could be found that the equations of first degree could be applied to the curves of growth in the groups TN, TS, S, N, and 1, while the equation of the second degrre could be applied to the curve in the group T...... and the tendency of all curves seemed to be similar to each other. Studies on the chemical analysis of the acid fraction is being continued.
