YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on Synthetic Estrogens. I
Synthesis of Diethylstilbesterol
Shigeru YoshidaSaburo Akagi
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1952 Volume 72 Issue 3 Pages 317-318

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Abstract
α, β-Dihydroxy-α, α-dianisylbutane was obtained by the reaction of p-methoxybenzoyl-ethyl carbinol and 4-methoxyphenylmagnesium bromide. By distillation under reduced pressure or treatment in 30% sulfuric acid with heating, the former gave α, α-dianisyl-β-butanone. Treatment of β-hydroxy-α, β-dianisyl-α-ethylbutane with phosphorylchloride with heating yielded 4, 4′-dimethoxy-α, β-diethylstilbene.
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