Abstract
Acylation of thiosemicarbazide with acid chloride in acetone in the presence of sodium bicarbonate or an excessive amount of thiosemicarbazide or in pyridine gives acylthio-semicarbazide, the treatment of which with concentrated sulfuric acid yields 2-amino-thiodiazole derivatives possessing a substituent in the 5-position. The acid chloride used were acetyl, propionyl, butyryl, benzoyl, p-nitrobenzoyl and phenylacetyl chlorides.
