チオ尿素化合体の研究 (第3報)

アリルチオ尿素類の抗菌作用

抄録

Growth inhibitory action in vitro against Mycobacterium tuberculosis (Aviann type A 67 strain) was tested with 24 kinds of arylthiourea synthesized. Of these tested, 2-hydroxy-, 2-amino- and a new compound 2, 6-dihydroxyphenylthiourea showed a remarkable inhibitory power about the same as or a little better than that of tibione used as a control, which seems to show that arylthiourea possessing a hydroxyl or an amino group in the ortho position shows a strong growth inhibition. The minimum concentration at which growth is inhibited with human type tubercie bacilli (H₂ strain) is similar to that against avian type bacilli. No noticeable effect was found with in vitro growth inhibition test of these compounds against Staphylococcus aureus (Terashima strain) and Escherichia Coll.