Abstract
Heating of allithiamine (IV) in solvents of high boiling point, such as ethylene glycol and cyclohexanol, results in the formation of thiochrome (II), 3-[2′-methyl-4′-amino-pyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazole-2-thione (SB1) (V), allyl mercaptan, and diallyl disulfide. The heating of (IV) in aqueous alkali solution results in the formation of allyl mercaptan, thiamine (VI), (II), and (V). In these cases, the formation of thiamine-thiazolone (III) was detected by the paper partition chromatography but it could not be isolated in a crystalline form.
