含窒素環化合物の合成 (第87報)

5-アミノチアゾール誘導体について その2

抄録

2-Hydroxy-5-benzalaminothiazole was obtained by the application of COS on benzal-aminoacetonitrile in alcohol. 2-Hydroxy-5-arylideneaminothiazoles are formed when COS is applied on aminoacetonitrile and aromatic aldehydes in a mixture of alcohol and ethyl acetate. Condensation of alkyl halides, allyl bromide, or benzyl chloride with the sodium salts of these 2-hydroxy compounds gave the corresponding alkoxy (allyloxy or benzyloxy)-5-arylideneaminothiazoles. Of the latter, 2-ethoxy-5-benzalaminothiazole was also obtained by the application of benzalaminoacetonitrile on ethylxanthoacetic acid.