YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on γ-Butyrolactone Derivatives. II
Synthesis of β, γ-and α, β, γ-Substituted Butyrolactones
Shigeo Obata
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1953 Volume 73 Issue 12 Pages 1298-1300

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Abstract
Sixteen kinds of β, γ- or α, β, γ-substitution products of γ-butyrolactone, including 13 new compounds, were prepared by heating under stirring with 85% sulfuric acid the ethyl esters of β-hydroxy acids obtained by the Reformatzsky reaction of various ketones and ethyl esters of α-bromo fatty acids. The compounds synthesized were all oily substances possessing individually characteristic aroma, and their hydrazinolactones were generally difficult to crystallize with the exception of the α, γ-substituted products and α, β, γ-substituted products possessing cyclohexyl ring which were comparatively easy to crystallize.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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