Abstract
For the purpose of preparing antitubercular chemotherapeutics with thiazole nucleus, 2-substituted 5-formylthiazole derivatives were prepared by the condensation of acetyl-, benzoyl-, phenylacetyl-, phenyl-, acetaminobenzenesulfonyl-, or aminobenzenesulfonyl-thioureas, thioacetamide, and diphenylthiourea with bromomalonic dialdehyde. Reaction of thiosemicarbazide with these compounds yielded eight kinds of corresponding thiazole-aldehyde thiosemicarbazones. Antitubercular action of 2-acetaminothiazole-5-aldehyde thiosemicarbazone and 2-benzoylaminothiazole-5-aldehyde thiosemicarbazone was tested using Tibione as the control from which it was learned that the former possessed about an equal efficacy as Tibione and the latter, about one-half the efficacy.
