キノリン誘導体の合成研究 (第4報)
炭素3個の側鎖をもつ8-Aminoquinoline類の合成
1953 年 73 巻 3 号 p. 290-292
詳細
1953 年 73 巻 3 号 p. 290-292
Diethylaminoisopropyl (I), 1, 3-bis (diethylaminoisopropyl) (II), 3-diethylamino-2-hydroxypropyl (III), and diethylaminopropyl (IV) groups were introduced into the amino radical of 8-amino- and 6-methoxy-8-aminoquinolines. The compounds were purified by derivation to crystalline picrates. In the above case, 3-diethylamino-1, 2-dihydroxy-propane was reduced with hydriodic acid and red phosphorus and reacted with the aminoquinoline, in order to obtain (I), but a mixture of approximately equal amounts of the iso compound (I) and normal compound (IV) was obtained. These two were easily separated by deriving them to respective monopicrate.
