Synthetic Studies in Quinoline Series. V

Synthesis of 6-Methoxy-8-(γ-diethylaminopropyl)-aminoquinoline using Trimethyleneglycol Monobutyl Ether, one of the By-products of Acetone-Butanol Fermentation

Abstract

Hydrolysis with sodium hydroxide of 10kg. of the distillation residue of crude butanol, obtained by butanol fermentation, yielded 4050g. of neutral portion and 3200g. of acid portion. The neutral portion gave 135g. of trimethyleneglycol monobutyl ether from which 6-methoxy-8-(γ-diethylaminopropyl)-aminoquinoline was prepared.