抄録
Heating of 2-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-formamino-5-hydroxy-Δ2-pentenyl-(3) alkyl disulfide (vitamin B1 alkyl disulfide) (I) in cyclohexanol results in its decomposition to thiochrome (III) and 3-[2′-methyl-4′-methylpyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazole-3-thione (SB1) (IV). Heating of vitamin B1 disulfide (II) in ethylene glycol results in its decomposition to (III) and 3-[2′-methyl-4′-methyl-pyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazol-2-one (vitamin B1-thiazolone) (V), with a minute amount of (IV) as a by-product which was confirmed by the paper partition chromatography. Heating of (I) in alkaline medium results in the formation of vitamin B1 (VI), (II), (III), (IV), and (V), while the similar heating of (II) yields (VI), (III) (IV), and (V). These components were all proved by the paper partition chromatography. Heating of (I) with hydrochloric acid results in its decomposition into formic acid, 2-methyl-4-amino-5-aminomethylpyrimidine, (VII), and α-aceto-γ-hydroxypropyl alkyl disulfide.
