化学療法剤の研究 第38報

2,5-Diaminopyrimidine誘導体について

抄録

Application of benzaldehyde to 2, 5-diamino-4-methyl-6-hydroxypyrimidine (II) results in condensation, not at 2-amino group but at 5-amino group, to form 2-amino-4-methyl-5-benzylideneamino-6-hydroxypyrimidine (III). The fact that the reaction product of (II) and benzoyl chloride is 2-amino-4-methyl-5-benzoylamino-6-hydroxypyrimidine (IX) was confirmed by the synthesis of the latter by another method.