1954 年 74 巻 10 号 p. 997-999
1-Isonicotinoyl-2-vanillylidene hydrazine (II), vanillic acid hydrazide (III), 1-vanilloyl-2-vanillylidene hydrazine (IV), isonicotinaldehyde semicarbazone (V), 1-vanilloyl-2-isonicotinidene hydrazine (VI), and 1-isonicotinoyl-2-isonicotinidene hydrazine (VII) were prepared and their antibacterial action against H 37 Rv strain of tubercle bacilli was tested in a Kirchner medium containing 10% bovine serum. (VII) was found to be 5-10 times more effective than isonicotinic acid hydrazide. By comparing the effective dilution of these compounds, it was concluded that the reason why (II) and (VI) were somewhat effective was not due to the vanillin skeleton but to the presence of a γ-picoline ring.