Abstract
Allied compounds of papaverine possessing a sulfur-containing substituent in 1-position are comparatively few. Considering the marked analgesic action of thiophene derivatives known recently, such compounds possessing thiophene nucleus in 1-position of isoquinoline derivatives seemed of interest as to their physiological activity. Following three compounds were prepared from ordinarily used amines and α-thiophenecarboxylic acid: 1-(2′-Thienyl)-3-methyl-6, 7-methylenedioxyisoquinoline (I), 1-(2′-thienyl)-3-methyl-6, 7-methylenedioxy-3, 4-dihydroisoquinoline (II), and 1-(2′-thienyl)-6, 7-dimethoxy-3, 4-dihydroisoquinoline (III). Of these, (I) showed approximately one-fifth the analgesic action of 3-dimethylamino-1, 1-di (2′-thienyl) butene-1. The papaverine-like action of these compounds are being examined.
