Studies on the Application of Polyphosphoric Acid as a Condensing Agent. II

Nuclear Acylation of Phenol and Anisole by Means of Carboxylic Acids. (Syntheses of 4-Hydroxy- and 4-Methoxyacylophenones)

Abstract

By heating phenol and anisole with free carboxylic acids, in the presence of polyphosphoric acid, for 5-30 minutes in boiling water bath, 4-hydroxy- and 4-methoxyacylophenones were respectively obtained. The present method has made it possible to prepare 4-hydroxyacylophenones quite easily from phenol and carboxylic acids instead of the various indirect methods practiced to date.