YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
Studies on the Application of Polyphosphoric Acid as a Condensing Agent. II
Nuclear Acylation of Phenol and Anisole by Means of Carboxylic Acids. (Syntheses of 4-Hydroxy- and 4-Methoxyacylophenones)
Koichi NakazawaShin MatsuuraKosuke Kusuda
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1954 Volume 74 Issue 5 Pages 495-497

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Abstract

By heating phenol and anisole with free carboxylic acids, in the presence of polyphosphoric acid, for 5-30 minutes in boiling water bath, 4-hydroxy- and 4-methoxyacylophenones were respectively obtained. The present method has made it possible to prepare 4-hydroxyacylophenones quite easily from phenol and carboxylic acids instead of the various indirect methods practiced to date.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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