鎭痛剤としてのHydro化Quinoline類及びIsoquinoline類の合成研究 (第1報)

8又は10-Alkyldecahydroquinoline類の合成

抄録

Based on the fact that a part of the morphine skeleton contains a decahydroisoquinoline ring, some hydroisoquinolines of such series and related hydroquinoline derivatives were studied in connection with the analgesic action that might be shown by these compounds. As a preliminary, 10-phenyl- and 10-anisyldecahydroquinolines were prepared by the high pressure catalytic reduction of 2-substituted 2-(β-cyanoethyl)-cyclohexane and 8-cyclohexyldecahydroquinoline by the same procedure from 6-cyclohexylidene-2-(β-cyanoethyl)-cyclohexanone. The N-alkyl derivatives were totally devoid of or possessed only a weak analgesic action.