ジアゾ化合物の反応 (第4報)

dl-ジセントリン合成に於けるPschorr反応の検討

抄録

In preparing dicentrine by the Pschorr reaction of 1-(3′, 4′-dimethoxy-6′-amino)-benzyl-2-methyl-6, 7-methylenedioxytetrahyroisoquinoline, the concurrent use of methanol or ethanol with copper dust as a reduction agent gives a better yield. The use of hypophosphoric acid as the reduction agent results in comparatively large formation of a deaminated compound and occurrence of an unwarranted side-reaction.