フラン誘導体の化学的並びに実験化学療法的研究 第17報

ナイトロフリルアクリル酸誘導体の抗菌性に就いて

抄録

2-(5-Nitro) furanacrylanilide and 24 of its allied compounds were prepared and the effect of the kind and position of the substituent in the benzene ring on antibacterial action was examined with Staphylococcus aureus P 209, Streptococcus hemolyticus, and Shigella dysenteriae Komagome B III. It was thereby found that the presence of a hydroxyl in the benzene ring effected the strongest action and that the action was stronger in para- and meta-substituted compounds. Compounds with two or more substituents generally showed lower antibacterial action but an aminothymol derivative showed the strongest action against staphylococci and streptococci.