海人草成分の藥理学的研究 (第4報)

抄録

The magnesium salt present in the aqueous extract of Digenea simplex suppresses oxygen uptake of the homogenized muscle of Ascaris suilla but such action is not observed with kainic acid. Anthelmintic action of the magnesium salts of lactic acid and kainic acid, the components of Digenea, was examined in vitro from which it was found that these salts possessed strong effect on the nonoxygen respiration of the nerve muscles of Allolobophora eoetida, earthworm, nerve muscle preparation of the upper tail of hog ascaris, and homogenized muscles of hog ascaris. Oral administration of these magnesium salts in a puppy showed that magnesium kainate was extremely effective in a small amount and that magnesium lactate was effective, though the efficacy was somewhat weaker. The anthelmintic mechanism of kainic acid is assuumed to be the excitement and paralysis of the muscle movement and inhibition of respiration in ascaris. Suppression of tissue respiration by kainic acid was found to be due to the decomposition of iron-containing respiration enzyme contained in the epithelial cells of the digestive tract of hog ascaris, as a result of histological examination of the hog ascaris immersed in a solution of kainic acid and of chemical examination of enzymes in the tissues of digestive tract of the ascaris.