海人草有効成分ならびに関連化合物の研究 第19報
Kainic Acid の異性化ならびに異性体に関する研究 (5) α-Kainic Acid Lactone
1955 年 75 巻 8 号 p. 916-919
詳細
1955 年 75 巻 8 号 p. 916-919
Treatment of α-kainic acid (α-I) with mineral acids results in the formation of a δ-lactone ring between one of the carboxyls and the tertiary carbon in the isopropenyl group, forming α-kainic acid lactone (α-XV). Its acetylation yields α-N-acetylkainic acid lactone (α-XVI), whose methylation yields methyl α-N-acetylkainate lactone (α-XVII). (α-XVI) is also obtained by the lactonization of N-acetylkainic acid (α-II) and its hydrolysis gives (α-XV). The reaction mother liquor left after lactonization of (α-I) yielded α-isokainic acid (α-XVIII), probably an isomer of (α-I).
