鎭痙剤の研究 (第7報)
フェニルグリシン系鎭痙剤の薬理作用
1955 年 75 巻 8 号 p. 979-982
詳細
1955 年 75 巻 8 号 p. 979-982
1) The derivatives of β-phenylethyl alcohol possess only a weak antispasmodic action while those of α-aminophenylacetic acid esters are strong antispasmodics.
2) The compounds of the 1st and 5th groups possess excellent antiacetylcholinic and antibarium actions and the esters are more powerful when the ester group is not lower alkyls but isoamyl or more especially, cyclohexyl group. The compounds are also powerful when the tertiary amino group is a lower one, such as dimethylamino and diethylamino, the action decreasing with the increase of the number of carbons in the allyl group.
3) With the exception of No. 16, the compounds of 2nd and 3rd groups showed only a weak antispasmodic acitivity.
4) The compounds of the 4th group possess antibarium and antihistaminic actions similar to those of 1st group but their antiacetylcholinic action is much weaker.
5) Contrary to expectations, the acitivity was not increased in compounds of the 6th group, only their antihistaminic action alone being better than the compounds of other groups.
