錠剤の管理 (第4報)

錠剤成型圧力の測定 その2

抄録

Using the usual tabletting machine used in the factory and without changing the amount of granules supplied, two kinds of granules were submitted to tabletting at a constant tabletting speed, the same mortar volume, and in three positions of the upper pounder (giving three different thicknesses of tablet), and correlation between the forming pressure measured and various characters of the products was examined. From such results, following points were clarified:
1) Naturally, there was no relation between pressure and weight of the tablet but differentiation by the position of the upper pounder (thickness of tablets) showed that there existed a positive correlation within each stratum. Appearance of such correlation in the case of one of the granules was found to be the interference of the change in the amount of granules supplied into the factor of the position of the upper pounder.
2) There is a negative correlation between pressure and thickness but differentiation by the thickness indicated the presence of a positive correlation. This indicates that there is a positive correlation between weight and thickness.
3) There is positive correlation between pressure and the quotient of weight by thickness.
4) There is a positive correlation between pressure and compressive strength.
5) Within the conditions used in the present experiments, no difference was found in the results from two kinds of granules.