Abstract
Reactivity of the two methyl groups in 2, 5-dimethyl-1, 3, 4-thiadiazole (I) was examined. (I) reacts with benzaldehyde to form a mono- and distyryl derivatives but the methiodide of (I) only forms a mono derivative with benzaldehyde, p-nitrobenzaldehyde, p-dimethylaminobenzaldehyde, or p-nitrosodimethylaniline. Application of bromoacetophenone or p-nitrobromoacetophenone to (I) affords a quaternary base and its treatment with alkali failed to yield the expected thiadiazolylpyrrole derivative, affording crystals assumed from its various properties to be the pseude base.
