Pyridin-及びChinolin-N-oxydに対するTosylchloridの反応
1956 年 76 巻 12 号 p. 1421-1422
詳細
1956 年 76 巻 12 号 p. 1421-1422
The reaction of pyridine 1-oxide and tosyl chloride in boiling nitrobenzene affords N-(α′-pyridyl)-α-pyridone p-tosylate in 35% yield. The anhydrate of quinoline 1-oxide (I), when allowed to stand over night in chloroform solution with tosyl chloride, forms p-tosylate of (I) while the solution of the hydrate of (I) in chloroform, dried over sodium sulfate and refluxed with tosyl chloride, forms p-tosylate of carbostyril (II). Decomposition of its recrystallization mother liquor affords (II), 4-chloroquinoline, and N-(α′-quinolyl)carbostyril.
