α-Lipoic Acid及び其の類縁化合物の研究 (第3報)

Ethyl DL-Diacetyldihydro-α-lipoateとAmineとの反応

抄録

In vitro transacetylation was attempted between 1 mole of ethyl DL-diacetyldihyd-ro-α-lipoate and 2 moles of aniline or benzylamine. In the case of aniline, 1 mole of aniline changed to acetanilide and only the acetyl group in S⁸-position easily underwent transition, while that in S⁶-position remained resistant. In the case of benzylamine, 2 moles of the amine changed to benzylacetamide and the acetyl groups in both S⁸-and S⁶-positions were found to undergo transition. Such difference occurs by the difference in the basicity of the two amines.