Studies on the Essential Oil of Artemisia capillaris THUNB. V

Antifungal Activity of the Essential Oil. (5). Treatment of Experimental Trichophytia by Ointment containing the Essential Oil

Abstract

The essential oil of Artemisia capillaris THUNB., which was found to have a powerful growth inhibition and bateriocidal action on dermatophytes, was found to show toxicity, LD₅₀, of 0.24±0.019cc./kg. by intraperitoneal injection in mice. Physicochemical stability of its ointment and periodical change of ointment potency were examined. The ointment showed good results in experimental trichophytia in guinea pigs, and it was confirmed that no recurrence of trichophytia was evident a few days after cessation of treatment.