Studies on the Syntheses of 1-Substituted Isoquinoline from α-Acylaminocinnamic Acids

Abstract

Since the azlactones of α-acylaminocinnamic acids are easily available, synthesis of 1-substituted isoquinolines from these azlactones through α-acylcinnamic acid, β-acylaminostyrene, and acyl-β-phenethylamide was examined. It was thereby found that 1-phenyl and 1-(3, 4-dimethoxyphenyl)-6, 7-dimethoxy isoquinolines could be prepared by this route and a new compound, 1-(3, 4-dimethoxyphenyl) isoquinoline, was synthesized. However, attempt to prepare 3-substituted norharmanes from α-acylamino-β-indolylacrylic acids failed.