Studies on the Change of Thioacetazone in vivo. VIII

On the Tuberculostatic Effects of the Decomposition Products of Thioaetazone

Abstract

Antibacterial action of chief decomposition products of thioacetazone was examined with human type tubercule bacilli H 37 RV strain. As shown in Table I, p-aminobenzaldehyde thiosemicarbazone alone was found to have about the same antibacterial action as that of thioacetazone. A 10:1 mixture of thioacetazone and its biological decomposition products was examined similarly and none of the decomposition products seemed to affect the antibacterial action of thioacetazone. In spite of the fact that the blood level of thioacetazone is low and tissue level is said to be generally lower than its blood level, thioacetazone is effective for various kinds of tubercular diseases and it is thought that an indirect action of thioacetazone, besides the direct action on the bacilli, cannot be disregarded.